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In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m2. Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.

 In the paint industry, titanium dioxide is used as a pigment to provide a brilliant white color and enhance the durability and weather resistance of coatings

5. Is EFSA banning titanium dioxide? 

 Another area where chemical product manufacturers make a significant impact is in the householdchemical products manufacturer. Cleaning products, laundry detergents, and personal care items such as shampoo and lotion are all made by these companies. These products make our lives easier and more comfortable, allowing us to maintain cleanliness and hygiene with ease.
Lithopone, I may state, is a mixture of zinc sulfid and barium sulfate which has lately been placed upon the market as a very desirable material for use in the manufacture of paints or as a substitute for white lead. The standard grade of this product contains 29.4 per cent. of zinc sulfid, which, as will be seen, is a molecular mixture of the two ingredients named.
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Genotoxicity refers to the ability of a chemical substance to damage DNA , the genetic material of cells. As genotoxicity may lead to carcinogenic effects, it is essential to assess the potential genotoxic effect of a substance to conclude on its safety.  

Suppliers of TiO2 can be categorized based on their production methods, which include the sulfate process and the chloride process. The sulfate process yields less expensive TiO2 but may contain impurities, while the chloride process produces higher quality, more expensive grades of TiO2. Buyers need to assess which type best suits their needs and budget.