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Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation. 

Another important trend in the wholesale TiO2 market is the growing demand for high-performance TiO2 grades. End-use industries such as paints and coatings are increasingly demanding TiO2 grades that offer superior performance in terms of opacity, whiteness, and durability
wholesale
wholesale tio2 market. As a result, manufacturers are investing in research and development to develop new and innovative TiO2 grades that meet these performance requirements.